|
KMID : 1134820140430020238
|
|
Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 2 p.238 ~ p.242
|
|
|
Immunomodulatory Activity of Crude Polysaccharides from Makgeolli
|
|
Cho Chang-Won
Rhee Young-Kyoung
Lee Young-Chul
Kim Young-Chan
Shin Kwang-Soon
Nam So-Hyun
Hong Hee-Do
|
|
|
Abstract
|
|
|
|
In this study, the immunomodulatory activities of crude polysaccharides from makgeolli were investigated. Crude polysaccahrides from makgeolli (RWW) were isolated by hot water extraction (100°C, 30 min), ethanol precipitation (four volumes of 95% ethanol), dialysis (MWCO: 6,000～8,000), and lyophilization. The major constituents in RWW were neutral sugar (87.3%), uronic acid (2.5%), and protein (10.2%). RWW showed potent anti-complementary activity as well as increased cell proliferation of RAW 264.7 macrophages. The immunomodulatory effects of RWW were also analyzed based on cytokine production of macrophages. Macrophages stimulated with RWW produced cytokines such as interleukin (IL)-6, IL-12, and tumor necrosis factor-α in a dose-dependent manner. These data indicate that RWW may have immunomodulatory effects through activation of the complement system and macrophages, which are a part of natural immunity.
|
|
|
KEYWORD
|
|
|
makgeolli, polysaccharide, immunomodulating activity, anti-complementary activity, macrophage
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|